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KMID : 0357319940290050411
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Journal of the Korean Society for Microbiology
1994 Volume.29 No. 5 p.411 ~ p.435
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The Contents of 8-Hydroxydeoxyuanine in the DNA of Human Gastric Mucosa Infected with Helicobacter pylori(1)
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윤희상
이우곤/조명제/강경희/박철근/정명희/손영숙/이광호
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Abstract
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Helicobacter pylori is the causative agent of type B chronic gastritis and a possible major determinant in hypothetical carcinogenesis of stomach cancer. The outline of the hypothesis is as followed; oxygen free radicals, as a well known mutagen,
which
are persistently produced by infiltrating inflammatory cells at gastric mucosa of patients with chronic gastritis injure DNA of gastric epithelial stem cells and induce stomach cancer after all. In this study, urease test and
8-hydroxydeoxyguanine(8-OH-dG) test were simultaneously performed by using gastric biopsy specimens collected from 68 young children in order to test the validity of the hypothesis.
The mean values of 8-OH-dG/10E5×dG of urease-positive group and urease-negative group were 7.5±8.7 and 5.1±6.9, respectively. There was no significant correlation between 8-OH-dG contents and urease activity of gastric biopsy specimens(Student
t
test). Therefore it is a prerequisite that normal specimens, as a negative control, should be obtained from persons who are confirmed not to be infected with Helicobacter pylori.
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